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Title   방사선 치료가 암환자의 염색체에 미치는 세포 유전학적 영향 ( Cytogenetic Effects of Radiotherapy on Peripheral Blood Lymphocytes of Cancer Patients )
Publicationinfo   1997 Jan; 029(02): 299-309.
Key_word   Chromosome aberration, Radiotherapy, Cancer
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Abstract   Purpose: To evaluate the frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients before and after radiotherapy. Materials and Methods: Thirty cases with various types of cancers such as rectum, lung, uterine cervix, lymphoma, and etc. were studied. The time of analyses was within 1 month after radiotherapy. The mean total radiation dose was 54 Gy. Results: The incidence of aberrant metaphases prior to radiation treatment was 2.2% and increased significantly after treatment to 29.7%(p<0.001). Also the number of chromosomal aberrations per cell was increased by a factor of 38.5. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentrics, acentrics, derivatives and translocations were increased by a factor of 155.5, 99, 55.5 and 23.8, respectively, after radiation treatment. Breakages were located at all chromosomes except Y chromosome and total number of identifiable breakages was 426 in 900 observed lymphocyte metaphases. Distribution of break points revealed the increase of number of break points in chromosome 1,2,5 and llq. Conclusion: Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies in radiation-treated cancer patients.
저 자   이형식(Hyung Sik Lee),최영민(Young Min Choi),허원주(Won Joo Heo),김경희(Kyung Hee Kim),신상동(Sang Dong Shin),한진영(Jin Young Han),김정만(Jung Man Kim),김효진(Hyo Jin Kim)